That small round scar is not a glitch in your skin, but a trace of one of humanity’s most aggressive medical battles. The mark is usually left by the BCG vaccine against tuberculosis or the older smallpox vaccine, both using live weakened microbes injected into the skin’s upper layers. Unlike today’s smooth, deep intramuscular shots, these older methods were designed to provoke a fierce, visible local reaction. A blister formed, then a scab, then a dense knot of disorganized collagen that settled into a permanent circular indentation.
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